Assay Detail
Binding
CHEMBL4146907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.30 | 8.87 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160691 | — | — | 1 | 8.87 |
| CHEMBL1069 | VALSARTAN | 4.0 | 1 | 8.52 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 7.98 |
| CHEMBL4175147 | — | — | 2 | 6.50 |
| CHEMBL4164514 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160691 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL1069 | VALSARTAN | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1016 | CANDESARTAN | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL4175147 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL4164514 | — | Ki | = | 24838.0 | nM | 4.61 |
| CHEMBL4175147 | — | Inhibition | - | % | - |