Assay Detail
ADMET
CHEMBL4146960
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Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.91 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.41 |
| CHEMBL4170740 | — | — | 1 | 5.29 |
| CHEMBL4162802 | — | — | 1 | 5.23 |
| CHEMBL4167348 | — | — | 1 | 5.09 |
| CHEMBL4162271 | — | — | 1 | 4.96 |
| CHEMBL4159444 | — | — | 1 | 4.93 |
| CHEMBL4160523 | — | — | 1 | 4.90 |
| CHEMBL4171124 | — | — | 1 | 4.86 |
| CHEMBL4172945 | — | — | 1 | 4.85 |
| CHEMBL4172197 | — | — | 1 | 4.84 |
| CHEMBL4174561 | — | — | 1 | 4.82 |
| CHEMBL4164308 | — | — | 1 | 4.77 |
| CHEMBL4176636 | — | — | 1 | 4.64 |
| CHEMBL4168776 | — | — | 1 | 4.53 |
| CHEMBL4163907 | — | — | 1 | 4.52 |
| CHEMBL4161527 | — | — | 1 | 4.46 |
| CHEMBL2012363 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4170740 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL4162802 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL4167348 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL4162271 | — | IC50 | = | 10960.0 | nM | 4.96 |
| CHEMBL4159444 | — | IC50 | = | 11820.0 | nM | 4.93 |
| CHEMBL4160523 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL4171124 | — | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL4172945 | — | IC50 | = | 14110.0 | nM | 4.85 |
| CHEMBL4172197 | — | IC50 | = | 14440.0 | nM | 4.84 |
| CHEMBL4174561 | — | IC50 | = | 15030.0 | nM | 4.82 |
| CHEMBL4164308 | — | IC50 | = | 16870.0 | nM | 4.77 |
| CHEMBL4176636 | — | IC50 | = | 23050.0 | nM | 4.64 |
| CHEMBL4168776 | — | IC50 | = | 29820.0 | nM | 4.53 |
| CHEMBL4163907 | — | IC50 | = | 30490.0 | nM | 4.52 |
| CHEMBL4161527 | — | IC50 | = | 34780.0 | nM | 4.46 |
| CHEMBL2012363 | — | IC50 | = | 51350.0 | nM | 4.29 |