Assay Detail
Binding
CHEMBL4146980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Gonadotropin-releasing hormone receptor (CHEMBL5647) ↗| Type | SINGLE PROTEIN |
| Organism | Macaca mulatta |
Publication
Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.42 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159247 | — | — | 1 | 8.46 |
| CHEMBL4173065 | — | — | 1 | 8.42 |
| CHEMBL4169891 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159247 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4173065 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4169891 | — | IC50 | = | 4.2 | nM | 8.38 |