Assay Detail
Binding
CHEMBL4147133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKKbeta (unknown origin) using FAM-P22 as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by mobility shift assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.97 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254461 | — | — | 1 | 5.18 |
| CHEMBL358894 | — | — | 1 | 5.14 |
| CHEMBL3314676 | — | — | 1 | 4.97 |
| CHEMBL4163966 | — | — | 1 | 4.85 |
| CHEMBL4177177 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254461 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL358894 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3314676 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4163966 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4177177 | — | IC50 | = | 19600.0 | nM | 4.71 |