Assay Detail
Binding
CHEMBL4147167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his-tagged bacterial VIM2 (27 to 266 residues) expressed in Escherichia coli BL21(DE3) pLyS cells
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.05 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177035 | — | — | 2 | 7.30 |
| CHEMBL4169182 | — | — | 2 | 5.97 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | 5.61 |
| CHEMBL434965 | D-CAPTOPRIL | — | 2 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177035 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4177035 | — | IC50 | = | 54.95 | nM | 7.26 |
| CHEMBL4169182 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL4169182 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 2454.71 | nM | 5.61 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 4570.88 | nM | 5.34 |