Assay Detail
Binding
CHEMBL4147168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his-tagged bacterial NDM1 expressed in Escherichia coli BL21(DE3) pLyS cells
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.34 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169182 | — | — | 2 | 4.61 |
| CHEMBL434965 | D-CAPTOPRIL | — | 2 | 4.21 |
| CHEMBL4177035 | — | — | 2 | 4.19 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169182 | — | IC50 | = | 24547.09 | nM | 4.61 |
| CHEMBL4169182 | — | IC50 | = | 24810.0 | nM | 4.61 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 62150.0 | nM | 4.21 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL4177035 | — | IC50 | = | 64565.42 | nM | 4.19 |
| CHEMBL4177035 | — | IC50 | = | 64770.0 | nM | 4.19 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 196800.0 | nM | - |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 194984.46 | nM | - |