Assay Detail
Binding
CHEMBL4147359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bacterial C-terminal His6-tagged ErmC' (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as decrease in rRNA methylation using [methyl-3H]AdoMet measured after 1 hr
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
rRNA adenine N-6-methyltransferase (CHEMBL4295568) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain N315) |
Publication
Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172068 | — | — | 1 | 4.00 |
| CHEMBL4164894 | — | — | 1 | - |
| CHEMBL4176470 | — | — | 1 | - |
| CHEMBL4166273 | — | — | 1 | - |
| CHEMBL4159029 | — | — | 1 | - |
| CHEMBL4169684 | — | — | 1 | - |
| CHEMBL2273057 | — | — | 1 | - |
| CHEMBL4159457 | — | — | 1 | - |
| CHEMBL4166678 | — | — | 1 | - |
| CHEMBL4175957 | — | — | 1 | - |
| CHEMBL4168106 | — | — | 1 | - |
| CHEMBL4172554 | — | — | 1 | - |
| CHEMBL4165617 | — | — | 1 | - |
| CHEMBL4162181 | — | — | 1 | - |
| CHEMBL4171668 | — | — | 1 | - |
| CHEMBL4161475 | — | — | 1 | - |
| CHEMBL4175510 | — | — | 1 | - |
| CHEMBL4168166 | — | — | 1 | - |
| CHEMBL4168716 | — | — | 1 | - |
| CHEMBL4174185 | — | — | 1 | - |
| CHEMBL4098242 | — | — | 1 | - |
| CHEMBL4162356 | — | — | 1 | - |
| CHEMBL4173033 | — | — | 1 | - |
| CHEMBL4165804 | — | — | 1 | - |
| CHEMBL4176416 | — | — | 1 | - |
| CHEMBL4169237 | — | — | 1 | - |
| CHEMBL4161309 | — | — | 1 | - |
| CHEMBL4172623 | — | — | 1 | - |
| CHEMBL4164726 | — | — | 1 | - |
| CHEMBL4173217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172068 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4176016 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4159457 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL2273057 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4169684 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4159029 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL4166273 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4176470 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4165860 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL4176579 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4165307 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4163790 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4175957 | — | IC50 | - | — | - | |
| CHEMBL4177311 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4170092 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4173546 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4176909 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4169047 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4161776 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4172416 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4164668 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4162820 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4170758 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4174185 | — | IC50 | - | — | - | |
| CHEMBL4173217 | — | IC50 | - | — | - | |
| CHEMBL4164726 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4172623 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL4161309 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4169237 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4176416 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4165804 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL4173033 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4162356 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4098242 | — | IC50 | = | 299000.0 | nM | - |
| CHEMBL4166678 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL4168716 | — | IC50 | - | — | - | |
| CHEMBL4168166 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4175510 | — | IC50 | - | — | - | |
| CHEMBL4164894 | — | IC50 | - | — | - | |
| CHEMBL4161475 | — | IC50 | - | — | - | |
| CHEMBL4171668 | — | IC50 | - | — | - | |
| CHEMBL4162181 | — | IC50 | - | — | - | |
| CHEMBL4165617 | — | IC50 | - | — | - | |
| CHEMBL4172554 | — | IC50 | - | — | - | |
| CHEMBL4168106 | — | IC50 | - | — | - |