Assay Detail
Binding
CHEMBL4147369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus ErmC' expressed in Bacillus subtilis BD170 assessed as decrease in rRNA methylation using [methyl-3H]AdoMet measured after 120 mins by beta-plate counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
rRNA adenine N-6-methyltransferase (CHEMBL4295563) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.35 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165736 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165736 | — | IC50 | = | 450.0 | nM | 6.35 |