Assay Detail
Binding
CHEMBL4147387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Plasmodium falciparum G6PD-6PGL using G6P as substrate in presence of NADP+ by Lineweaver-Burk plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase (CHEMBL4295620) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.39 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165870 | — | — | 1 | 6.72 |
| CHEMBL2170943 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165870 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2170943 | — | IC50 | = | 900.0 | nM | 6.05 |