Assay Detail
Binding
CHEMBL4147764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.51 | 6.75 |
| IC50 | 1 | 5.54 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165406 | — | — | 1 | 6.75 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.26 |
| CHEMBL408194 | OBATOCLAX | 3.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165406 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL443684 | NAVITOCLAX | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL408194 | OBATOCLAX | IC50 | = | 2900.0 | nM | 5.54 |