Assay Detail
Functional
CHEMBL4148161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against erythrocytic stage of Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 4.96 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330901 | — | — | 1 | 5.92 |
| CHEMBL4161579 | — | — | 1 | 5.85 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | 4.0 | 1 | 5.82 |
| CHEMBL3330913 | — | — | 1 | 5.82 |
| CHEMBL4172194 | — | — | 1 | 5.75 |
| CHEMBL3330900 | — | — | 1 | 5.72 |
| CHEMBL3330912 | — | — | 1 | 5.64 |
| CHEMBL4165001 | — | — | 1 | 5.57 |
| CHEMBL4168504 | — | — | 1 | 5.52 |
| CHEMBL4176362 | — | — | 1 | 5.50 |
| CHEMBL4167014 | — | — | 1 | 5.47 |
| CHEMBL3330902 | — | — | 1 | 5.43 |
| CHEMBL3330911 | — | — | 1 | 5.39 |
| CHEMBL3330910 | — | — | 1 | 5.37 |
| CHEMBL4159522 | — | — | 1 | 5.35 |
| CHEMBL3329237 | — | — | 1 | 5.25 |
| CHEMBL4174900 | — | — | 1 | 5.19 |
| CHEMBL1739045 | — | — | 1 | 5.19 |
| CHEMBL3330899 | — | — | 1 | 5.12 |
| CHEMBL4172699 | — | — | 1 | 5.09 |
| CHEMBL455392 | — | — | 1 | 5.09 |
| CHEMBL3330898 | — | — | 1 | 5.00 |
| CHEMBL3884203 | — | — | 1 | 4.99 |
| CHEMBL4166136 | — | — | 1 | 4.99 |
| CHEMBL4161190 | — | — | 1 | 4.95 |
| CHEMBL3885179 | — | — | 1 | 4.93 |
| CHEMBL3884036 | — | — | 1 | 4.92 |
| CHEMBL4162024 | — | — | 1 | 4.92 |
| CHEMBL2316805 | — | — | 1 | 4.91 |
| CHEMBL4171473 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330901 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4161579 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3330913 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4172194 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3330900 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3330912 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4165001 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4168504 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4176362 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4167014 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3330902 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3330911 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3330910 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4159522 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3329237 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4174900 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1739045 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3330899 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4172699 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL455392 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3330898 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3884203 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4166136 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4161190 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3885179 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4162024 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3884036 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL2316805 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4171473 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4173798 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3220025 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL3884615 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3220020 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3330903 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4165876 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3330914 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4166337 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3885376 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3884574 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4165924 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4168120 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4175337 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4174634 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL4163981 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4176541 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4163097 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL550524 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3330907 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL455151 | — | IC50 | = | 42100.0 | nM | 4.38 |