Assay Detail
Binding
CHEMBL4148198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma cruzi Y epimastigotes PAT assessed as reduction in [3H]-putrescine uptake after 10 mins by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Putative amino acid permease/transporter (CHEMBL4295536) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
Publication
Targeting polyamine transport in Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.44 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170844 | — | — | 1 | 5.61 |
| CHEMBL541629 | — | — | 1 | 5.40 |
| CHEMBL558390 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170844 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL541629 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL558390 | — | IC50 | = | 5020.0 | nM | 5.30 |