Assay Detail
Binding
CHEMBL4148417
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Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.33 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.05 |
| CHEMBL4170657 | — | — | 1 | 6.57 |
| CHEMBL4174681 | — | — | 1 | 6.57 |
| CHEMBL4160262 | — | — | 1 | 6.52 |
| CHEMBL4176950 | — | — | 1 | 6.52 |
| CHEMBL4159967 | — | — | 1 | 6.44 |
| CHEMBL4170484 | — | — | 1 | 6.30 |
| CHEMBL4170613 | — | — | 1 | 6.30 |
| CHEMBL4162548 | — | — | 1 | 6.27 |
| CHEMBL4166804 | — | — | 1 | 6.22 |
| CHEMBL4171652 | — | — | 1 | 6.11 |
| CHEMBL4176588 | — | — | 1 | 6.06 |
| CHEMBL4163626 | — | — | 1 | 6.03 |
| CHEMBL4168743 | — | — | 1 | 5.99 |
| CHEMBL4163778 | — | — | 1 | 5.93 |
| CHEMBL4174055 | — | — | 1 | 5.89 |
| CHEMBL4162279 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4170657 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL4174681 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL4160262 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL4176950 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL4159967 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL4170484 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL4170613 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL4162548 | — | Ki | = | 534.0 | nM | 6.27 |
| CHEMBL4166804 | — | Ki | = | 601.0 | nM | 6.22 |
| CHEMBL4171652 | — | Ki | = | 782.0 | nM | 6.11 |
| CHEMBL4176588 | — | Ki | = | 876.0 | nM | 6.06 |
| CHEMBL4163626 | — | Ki | = | 931.0 | nM | 6.03 |
| CHEMBL4168743 | — | Ki | = | 1033.0 | nM | 5.99 |
| CHEMBL4163778 | — | Ki | = | 1165.0 | nM | 5.93 |
| CHEMBL4174055 | — | Ki | = | 1285.0 | nM | 5.89 |
| CHEMBL4162279 | — | Ki | = | 1690.0 | nM | 5.77 |