Assay Detail
Binding
CHEMBL4148419
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Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.53 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176950 | — | — | 1 | 8.22 |
| CHEMBL4163778 | — | — | 1 | 8.22 |
| CHEMBL4170613 | — | — | 1 | 8.15 |
| CHEMBL4166804 | — | — | 1 | 8.10 |
| CHEMBL4174055 | — | — | 1 | 8.05 |
| CHEMBL4168743 | — | — | 1 | 8.00 |
| CHEMBL4170657 | — | — | 1 | 8.00 |
| CHEMBL4162279 | — | — | 1 | 7.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.75 |
| CHEMBL4159967 | — | — | 1 | 7.70 |
| CHEMBL4171652 | — | — | 1 | 7.64 |
| CHEMBL4176588 | — | — | 1 | 7.30 |
| CHEMBL4174681 | — | — | 1 | 7.07 |
| CHEMBL4163626 | — | — | 1 | 7.03 |
| CHEMBL4160262 | — | — | 1 | 6.67 |
| CHEMBL4170484 | — | — | 1 | 6.25 |
| CHEMBL4162548 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176950 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4163778 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4170613 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4166804 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4174055 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4168743 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4170657 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4162279 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4159967 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4171652 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4176588 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4174681 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL4163626 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL4160262 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL4170484 | — | Ki | = | 566.0 | nM | 6.25 |
| CHEMBL4162548 | — | Ki | = | 1205.0 | nM | 5.92 |