Assay Detail
Binding
CHEMBL4148442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent updates for designing CCR5 antagonists as anti-retroviral agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.97 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110727 | CENICRIVIROC | 3.0 | 1 | 9.60 |
| CHEMBL1255794 | APLAVIROC | 3.0 | 1 | 9.40 |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | 9.04 |
| CHEMBL1172035 | NIFEVIROC | — | 1 | 8.54 |
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110727 | CENICRIVIROC | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1255794 | APLAVIROC | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL82301 | VICRIVIROC | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL1172035 | NIFEVIROC | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL256907 | MARAVIROC | IC50 | = | 5.2 | nM | 8.28 |