Assay Detail
Functional
CHEMBL4148506
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Neuroprotection against CoCl2-induced toxicity in rat PC12 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.74 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166551 | — | — | 1 | 5.37 |
| CHEMBL4169973 | — | — | 1 | 4.76 |
| CHEMBL4177172 | — | — | 1 | 4.60 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166551 | — | EC50 | = | 4249.0 | nM | 5.37 |
| CHEMBL4169973 | — | EC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL4177172 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL303697 | LIGUSTRAZINE | EC50 | = | 60000.0 | nM | 4.22 |