Assay Detail
Functional
CHEMBL4148507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotection against CoCl2-induced toxicity in rat PC12 cells preincubated for 36 hrs followed by CoCl2 addition measured after 12 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.41 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165492 | — | — | 1 | 5.97 |
| CHEMBL4162047 | — | — | 1 | 5.78 |
| CHEMBL4173416 | — | — | 1 | 5.69 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165492 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4162047 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4173416 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL303697 | LIGUSTRAZINE | EC50 | = | 64460.0 | nM | 4.19 |