Assay Detail
Functional
CHEMBL4148514
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Anti-inflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta production after 24 hrs by ELISA
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.14 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165191 | — | — | 1 | 5.43 |
| CHEMBL54467 | — | — | 1 | 5.24 |
| CHEMBL4167624 | — | — | 1 | 4.76 |
| CHEMBL4174090 | — | — | 1 | - |
| CHEMBL4169086 | — | — | 1 | - |
| CHEMBL4173156 | — | — | 1 | - |
| CHEMBL4162469 | — | — | 1 | - |
| CHEMBL4176526 | — | — | 1 | - |
| CHEMBL4165911 | — | — | 1 | - |
| CHEMBL4161419 | — | — | 1 | - |
| CHEMBL4169342 | — | — | 1 | - |
| CHEMBL4172735 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL4173094 | — | — | 1 | - |
| CHEMBL4173587 | — | — | 1 | - |
| CHEMBL4171892 | — | — | 1 | - |
| CHEMBL4159386 | — | — | 1 | - |
| CHEMBL4165694 | — | — | 1 | - |
| CHEMBL4175982 | — | — | 1 | - |
| CHEMBL4173993 | — | — | 1 | - |
| CHEMBL4163279 | — | — | 1 | - |
| CHEMBL4167046 | — | — | 1 | - |
| CHEMBL4159862 | — | — | 1 | - |
| CHEMBL4170457 | — | — | 1 | - |
| CHEMBL4162526 | — | — | 1 | - |
| CHEMBL4173888 | — | — | 1 | - |
| CHEMBL4165962 | — | — | 1 | - |
| CHEMBL4175925 | — | — | 1 | - |
| CHEMBL4164019 | — | — | 1 | - |
| CHEMBL4165635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165191 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL54467 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4167624 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4171892 | — | IC50 | - | — | - | |
| CHEMBL4165667 | — | IC50 | - | — | - | |
| CHEMBL4173587 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4173094 | — | IC50 | - | — | - | |
| CHEMBL63 | ROLIPRAM | IC50 | - | — | - | |
| CHEMBL4172735 | — | IC50 | - | — | - | |
| CHEMBL4169342 | — | IC50 | - | — | - | |
| CHEMBL4161419 | — | IC50 | - | — | - | |
| CHEMBL4165911 | — | IC50 | - | — | - | |
| CHEMBL4176526 | — | IC50 | - | — | - | |
| CHEMBL4162469 | — | IC50 | - | — | - | |
| CHEMBL4173156 | — | IC50 | - | — | - | |
| CHEMBL4169086 | — | IC50 | - | — | - | |
| CHEMBL4174090 | — | IC50 | - | — | - | |
| CHEMBL4159386 | — | IC50 | - | — | - | |
| CHEMBL4165694 | — | IC50 | - | — | - | |
| CHEMBL4175982 | — | IC50 | - | — | - | |
| CHEMBL4173993 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4163279 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4167046 | — | IC50 | - | — | - | |
| CHEMBL4159862 | — | IC50 | - | — | - | |
| CHEMBL4170457 | — | IC50 | - | — | - | |
| CHEMBL4162526 | — | IC50 | - | — | - | |
| CHEMBL4173888 | — | IC50 | - | — | - | |
| CHEMBL4165962 | — | IC50 | - | — | - | |
| CHEMBL4175925 | — | IC50 | - | — | - | |
| CHEMBL4164019 | — | IC50 | - | — | - | |
| CHEMBL4165635 | — | IC50 | - | — | - |