Assay Detail
Functional
CHEMBL4148528
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Antiproliferative activity against human HeLa cells after 2 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.69 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167073 | — | — | 1 | 8.92 |
| CHEMBL330407 | — | — | 1 | 8.59 |
| CHEMBL4159163 | — | — | 1 | 8.59 |
| CHEMBL4177274 | — | — | 1 | 8.59 |
| CHEMBL4176195 | — | — | 1 | 8.57 |
| CHEMBL4165779 | — | — | 1 | 8.48 |
| CHEMBL4173388 | — | — | 1 | 8.47 |
| CHEMBL4173698 | — | — | 1 | 8.43 |
| CHEMBL4173924 | — | — | 1 | 8.32 |
| CHEMBL4167723 | — | — | 1 | 8.32 |
| CHEMBL4165993 | — | — | 1 | 8.30 |
| CHEMBL4172019 | — | — | 1 | 7.82 |
| CHEMBL4159494 | — | — | 1 | 7.77 |
| CHEMBL4169211 | — | — | 1 | 7.68 |
| CHEMBL4175956 | — | — | 1 | 7.68 |
| CHEMBL4161269 | — | — | 1 | 7.64 |
| CHEMBL4177069 | — | — | 1 | 7.64 |
| CHEMBL4169423 | — | — | 1 | 7.62 |
| CHEMBL4171389 | — | — | 1 | 7.40 |
| CHEMBL4161939 | — | — | 1 | 7.40 |
| CHEMBL4175841 | — | — | 1 | 7.30 |
| CHEMBL4161405 | — | — | 1 | 7.22 |
| CHEMBL4172595 | — | — | 1 | 6.89 |
| CHEMBL4167049 | — | — | 1 | 6.70 |
| CHEMBL4172465 | — | — | 1 | 6.50 |
| CHEMBL4175470 | — | — | 1 | 6.46 |
| CHEMBL4160752 | — | — | 1 | 6.43 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167073 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL330407 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4159163 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4177274 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4176195 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4165779 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4173388 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4173698 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4173924 | — | IC50 | = | 4.79 | nM | 8.32 |
| CHEMBL4167723 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4165993 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4172019 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4159494 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4169211 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4175956 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4161269 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4177069 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4169423 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4171389 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4161939 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4175841 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4161405 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4172595 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4167049 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4172465 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4175470 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL4160752 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2100.0 | nM | 5.68 |