Assay Detail
Functional
CHEMBL4148529
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Antiproliferative activity against human A549 cells after 2 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.52 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167723 | — | — | 1 | 7.11 |
| CHEMBL4173698 | — | — | 1 | 7.05 |
| CHEMBL4173924 | — | — | 1 | 7.00 |
| CHEMBL4172019 | — | — | 1 | 6.96 |
| CHEMBL330407 | — | — | 1 | 6.93 |
| CHEMBL4165993 | — | — | 1 | 6.89 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.89 |
| CHEMBL4171389 | — | — | 1 | 6.89 |
| CHEMBL4165779 | — | — | 1 | 6.85 |
| CHEMBL4177069 | — | — | 1 | 6.85 |
| CHEMBL4167073 | — | — | 1 | 6.82 |
| CHEMBL4176195 | — | — | 1 | 6.82 |
| CHEMBL4159163 | — | — | 1 | 6.80 |
| CHEMBL4173388 | — | — | 1 | 6.80 |
| CHEMBL4177274 | — | — | 1 | 6.75 |
| CHEMBL4175956 | — | — | 1 | 6.57 |
| CHEMBL4159494 | — | — | 1 | 6.50 |
| CHEMBL4161269 | — | — | 1 | 6.41 |
| CHEMBL4161405 | — | — | 1 | 6.40 |
| CHEMBL4175841 | — | — | 1 | 6.34 |
| CHEMBL4167049 | — | — | 1 | 6.26 |
| CHEMBL4169423 | — | — | 1 | 6.10 |
| CHEMBL4161939 | — | — | 1 | 6.05 |
| CHEMBL4169211 | — | — | 1 | 5.89 |
| CHEMBL4160752 | — | — | 1 | 5.82 |
| CHEMBL4172595 | — | — | 1 | 5.81 |
| CHEMBL4175470 | — | — | 1 | 5.52 |
| CHEMBL4172465 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167723 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4173698 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4173924 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4172019 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL330407 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4165993 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4171389 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4165779 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4177069 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4167073 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4176195 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4159163 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4173388 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4177274 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4175956 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4159494 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4161269 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4161405 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4175841 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4167049 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4169423 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4161939 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4169211 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4160752 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4172595 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4175470 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4172465 | — | IC50 | = | 3900.0 | nM | 5.41 |