Assay Detail
Binding
CHEMBL4148756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FITC-Ahx-Bim-OH binding to human Bcl2 isoform 2 after 2 hrs by fluorescent polarization assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.99 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172927 | — | — | 1 | 7.05 |
| CHEMBL4161200 | — | — | 1 | 6.43 |
| CHEMBL4162253 | — | — | 1 | 6.35 |
| CHEMBL4174087 | — | — | 1 | 6.21 |
| CHEMBL4176611 | — | — | 1 | 6.16 |
| CHEMBL4169123 | — | — | 1 | 6.08 |
| CHEMBL4169534 | — | — | 1 | 5.97 |
| CHEMBL4177395 | — | — | 1 | 5.85 |
| CHEMBL4175537 | — | — | 1 | 5.84 |
| CHEMBL4161959 | — | — | 1 | 5.84 |
| CHEMBL4177447 | — | — | 1 | 5.81 |
| CHEMBL4172616 | — | — | 1 | 5.75 |
| CHEMBL4171691 | — | — | 1 | 5.74 |
| CHEMBL4166826 | — | — | 1 | 5.65 |
| CHEMBL4164915 | — | — | 1 | 5.59 |
| CHEMBL4176314 | — | — | 1 | 5.54 |
| CHEMBL4168346 | — | — | 1 | - |
| CHEMBL4160437 | — | — | 1 | - |
| CHEMBL4175134 | — | — | 1 | - |
| CHEMBL4167271 | — | — | 1 | - |
| CHEMBL4162625 | — | — | 1 | - |
| CHEMBL4160019 | — | — | 1 | - |
| CHEMBL4163814 | — | — | 1 | - |
| CHEMBL4168747 | — | — | 1 | - |
| CHEMBL4163377 | — | — | 1 | - |
| CHEMBL4170660 | — | — | 1 | - |
| CHEMBL4167208 | — | — | 1 | - |
| CHEMBL4167274 | — | — | 1 | - |
| CHEMBL4175138 | — | — | 1 | - |
| CHEMBL4163818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172927 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL4161200 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4162253 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL4174087 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL4176611 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL4169123 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL4169534 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL4177395 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL4175537 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL4161959 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL4177447 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL4172616 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4171691 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL4166826 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL4164915 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL4176314 | — | Ki | = | 2920.0 | nM | 5.54 |
| CHEMBL4159296 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4165700 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4171694 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163818 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4175138 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4167274 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4167208 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4170660 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163377 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4168747 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4163814 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4160019 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4162625 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4167271 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4175134 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4160437 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4168346 | — | Ki | > | 23000.0 | nM | - |