Assay Detail
Binding
CHEMBL4149306
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Inhibition of TNFalpha stimulated NF-kappaB (unknown origin) expressed in HEK293 cells after 5 hrs by luciferase reporter gene based luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carbazole-, Aspidofractinine-, and Aspidocarpamine-Type Alkaloids from Pleiocarpa pycnantha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298697 | — | — | 1 | 6.40 |
| CHEMBL4176582 | — | — | 1 | 5.08 |
| CHEMBL4159999 | — | — | 1 | 5.06 |
| CHEMBL4159200 | — | — | 1 | 5.03 |
| CHEMBL4168718 | — | — | 1 | 4.88 |
| CHEMBL4167918 | — | — | 1 | - |
| CHEMBL2229719 | — | — | 1 | - |
| CHEMBL4173934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298697 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4176582 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4159999 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4159200 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4168718 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4167918 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2229719 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4173934 | — | IC50 | > | 50000.0 | nM | - |