Assay Detail
Functional
CHEMBL4149439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.92 | 5.43 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.43 |
| CHEMBL69863 | PICEATANNOL | — | 2 | 5.40 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 2 | 4.98 |
| CHEMBL165 | RESVERATROL | 3.0 | 2 | 4.87 |
| CHEMBL113029 | — | — | 2 | 4.71 |
| CHEMBL186366 | PINOSYLVIN METHYL ETHER | — | 2 | 4.62 |
| CHEMBL101506 | PINOSYLVIN | — | 2 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL69863 | PICEATANNOL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL83527 | PTEROSTILBENE | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL165 | RESVERATROL | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL113029 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL186366 | PINOSYLVIN METHYL ETHER | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL101506 | PINOSYLVIN | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL101506 | PINOSYLVIN | Activity | - | — | - | |
| CHEMBL186366 | PINOSYLVIN METHYL ETHER | Activity | - | — | - | |
| CHEMBL165 | RESVERATROL | Activity | - | — | - | |
| CHEMBL83527 | PTEROSTILBENE | Activity | - | — | - | |
| CHEMBL69863 | PICEATANNOL | Activity | - | — | - | |
| CHEMBL113029 | — | Activity | - | — | - |