Assay Detail
Binding
CHEMBL4149486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.84 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160447 | — | — | 1 | 8.00 |
| CHEMBL3890847 | — | — | 1 | 6.12 |
| CHEMBL4167678 | — | — | 1 | 5.96 |
| CHEMBL2381968 | — | — | 1 | 5.64 |
| CHEMBL4167472 | — | — | 1 | 5.13 |
| CHEMBL4165400 | — | — | 1 | 4.16 |
| CHEMBL4176009 | — | — | 1 | - |
| CHEMBL3186228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160447 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3890847 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4167678 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2381968 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4167472 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4165400 | — | IC50 | = | 69700.0 | nM | 4.16 |
| CHEMBL4176009 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3186228 | — | IC50 | > | 100000.0 | nM | - |