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Assay Detail

CHEMBL4149576

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of Plasmodium falciparum NF54 exflagellation measured on day 15 post parasite growth
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Plasmodial Kinase Inhibitors: License to Cure?
Cabrera DG, Horatscheck A, Wilson CR, Basarab G, Eyermann CJ, Chibale K.
J Med Chem (2018) 61 : 8061 -8077
PubMed 29771541 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 7.40 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2030554 1 7.46
CHEMBL2078876 1 7.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2030554 EC50 = 35.0 nM 7.46
CHEMBL2078876 EC50 = 47.0 nM 7.33