Assay Detail
Binding
CHEMBL4149974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.14 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356083 | — | — | 1 | 8.77 |
| CHEMBL4169726 | — | — | 1 | 8.70 |
| CHEMBL4159554 | — | — | 1 | 7.73 |
| CHEMBL4167803 | — | — | 1 | 7.54 |
| CHEMBL4164957 | — | — | 1 | 7.54 |
| CHEMBL4162351 | — | — | 1 | 7.39 |
| CHEMBL4173224 | — | — | 1 | 7.14 |
| CHEMBL4161479 | — | — | 1 | 6.93 |
| CHEMBL4162728 | — | — | 1 | 6.52 |
| CHEMBL4175581 | — | — | 1 | 6.49 |
| CHEMBL4164987 | — | — | 1 | 6.33 |
| CHEMBL4171236 | — | — | 1 | 6.22 |
| CHEMBL4170275 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356083 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4169726 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4159554 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL4167803 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL4164957 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL4162351 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL4173224 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL4161479 | — | IC50 | = | 116.5 | nM | 6.93 |
| CHEMBL4162728 | — | IC50 | = | 301.9 | nM | 6.52 |
| CHEMBL4175581 | — | IC50 | = | 327.5 | nM | 6.49 |
| CHEMBL4164987 | — | IC50 | = | 465.5 | nM | 6.33 |
| CHEMBL4171236 | — | IC50 | = | 598.9 | nM | 6.22 |
| CHEMBL4170275 | — | IC50 | = | 2869.0 | nM | 5.54 |