Assay Detail
Functional
CHEMBL4149991
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Antiproliferative activity against human KB cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.22 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.19 |
| CHEMBL3358557 | — | — | 1 | 6.90 |
| CHEMBL4159175 | — | — | 1 | 5.94 |
| CHEMBL4166766 | — | — | 1 | 5.78 |
| CHEMBL4167092 | — | — | 1 | 5.66 |
| CHEMBL4163642 | — | — | 1 | 5.49 |
| CHEMBL3359132 | — | — | 1 | 5.43 |
| CHEMBL4174318 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3358557 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4159175 | — | IC50 | = | 1143.0 | nM | 5.94 |
| CHEMBL4166766 | — | IC50 | = | 1665.0 | nM | 5.78 |
| CHEMBL4167092 | — | IC50 | = | 2182.0 | nM | 5.66 |
| CHEMBL4163642 | — | IC50 | = | 3234.0 | nM | 5.49 |
| CHEMBL3359132 | — | IC50 | = | 3691.0 | nM | 5.43 |
| CHEMBL4174318 | — | IC50 | = | 4542.0 | nM | 5.34 |