Assay Detail
Functional
CHEMBL4149992
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Antiproliferative activity against human MV411 cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.78 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 9.52 |
| CHEMBL4174318 | — | — | 1 | 7.61 |
| CHEMBL4163642 | — | — | 1 | 7.57 |
| CHEMBL3358557 | — | — | 1 | 7.55 |
| CHEMBL4167092 | — | — | 1 | 7.53 |
| CHEMBL4166766 | — | — | 1 | 7.53 |
| CHEMBL4159175 | — | — | 1 | 7.18 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4174318 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL4163642 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL3358557 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL4167092 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL4166766 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL4159175 | — | IC50 | = | 66.3 | nM | 7.18 |
| CHEMBL848 | LENALIDOMIDE | IC50 | > | 20000.0 | nM | - |