Assay Detail
Binding
CHEMBL4150231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human integrin alphaVbeta3 receptor using acetyl-CisoDGRCGVRSSSRTPSDKY-bio probe and streptavidin-peroxidase conjugate incubated for 3 hrs by competitive binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to αvβ3 without Promoting Integrin Allosteric Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.86 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 9.00 |
| CHEMBL4161189 | — | — | 1 | 8.20 |
| CHEMBL4168458 | — | — | 1 | 7.70 |
| CHEMBL4165038 | — | — | 1 | 7.67 |
| CHEMBL4160559 | — | — | 1 | 7.58 |
| CHEMBL4171425 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4161189 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4168458 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL4165038 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL4160559 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL4171425 | — | Ki | = | 103.0 | nM | 6.99 |