Assay Detail
Functional
CHEMBL4150520
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Antiviral activity against recombinant HCMV AD169 expressing GFP infected in human foreskin fibroblast assessed as reduction in virus-induced cytopathic effect after 7 days
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.74 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172318 | — | — | 1 | 6.25 |
| CHEMBL4173870 | — | — | 1 | 6.20 |
| CHEMBL4164438 | — | — | 1 | 6.16 |
| CHEMBL4172324 | — | — | 1 | 6.10 |
| CHEMBL4164443 | — | — | 1 | 5.74 |
| CHEMBL4160616 | — | — | 1 | 5.71 |
| CHEMBL4165942 | — | — | 1 | 5.67 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.58 |
| CHEMBL4175730 | — | — | 1 | 5.27 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 5.27 |
| CHEMBL4167874 | — | — | 1 | 5.18 |
| CHEMBL4167869 | — | — | 1 | - |
| CHEMBL4175726 | — | — | 1 | - |
| CHEMBL1672002 | THYMOQUINONE | 2.0 | 1 | - |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172318 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4173870 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4164438 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4172324 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4164443 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4160616 | — | EC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4165942 | — | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4175730 | — | EC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL4167874 | — | EC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL4167869 | — | EC50 | - | — | - | |
| CHEMBL4175726 | — | EC50 | - | — | - | |
| CHEMBL1672002 | THYMOQUINONE | EC50 | > | 10000.0 | nM | - |
| CHEMBL307261 | ARTENIMOL | EC50 | > | 10000.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | EC50 | > | 10000.0 | nM | - |