Assay Detail
Functional
CHEMBL4150522
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Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage parasites infected in human erythrocytes after 72 hrs by SYBR Green 1 dye based fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.06 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172318 | — | — | 1 | 8.43 |
| CHEMBL4164438 | — | — | 1 | 8.37 |
| CHEMBL4160616 | — | — | 1 | 8.36 |
| CHEMBL4173870 | — | — | 1 | 8.23 |
| CHEMBL4167874 | — | — | 1 | 8.16 |
| CHEMBL4175730 | — | — | 1 | 8.11 |
| CHEMBL4164443 | — | — | 1 | 8.09 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.09 |
| CHEMBL4175726 | — | — | 1 | 7.92 |
| CHEMBL4167869 | — | — | 1 | 7.91 |
| CHEMBL4165942 | — | — | 1 | 7.76 |
| CHEMBL4172324 | — | — | 1 | 7.27 |
| CHEMBL1672002 | THYMOQUINONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172318 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4164438 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4160616 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4173870 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4167874 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4175730 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4164443 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL361497 | ARTESUNATE | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4175726 | — | EC50 | = | 12.1 | nM | 7.92 |
| CHEMBL4167869 | — | EC50 | = | 12.2 | nM | 7.91 |
| CHEMBL4165942 | — | EC50 | = | 17.5 | nM | 7.76 |
| CHEMBL4172324 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1672002 | THYMOQUINONE | EC50 | > | 80000.0 | nM | - |