Assay Detail
Binding
CHEMBL4150584
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Inhibition of JAK2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after 25 mins in presence of ATP
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168763 | — | — | 1 | 9.00 |
| CHEMBL4175964 | — | — | 1 | 9.00 |
| CHEMBL4172110 | — | — | 1 | 9.00 |
| CHEMBL4159366 | — | — | 1 | 8.70 |
| CHEMBL4167286 | — | — | 1 | 8.70 |
| CHEMBL4164238 | — | — | 1 | 8.70 |
| CHEMBL4167685 | — | — | 1 | 8.70 |
| CHEMBL4160833 | — | — | 1 | 8.52 |
| CHEMBL4162254 | — | — | 1 | 8.40 |
| CHEMBL4175555 | — | — | 1 | 8.10 |
| CHEMBL4170168 | — | — | 1 | 8.10 |
| CHEMBL4169802 | — | — | 1 | 7.82 |
| CHEMBL4168707 | — | — | 1 | 7.80 |
| CHEMBL4165344 | — | — | 1 | 7.75 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 7.39 |
| CHEMBL4160840 | — | — | 1 | 7.07 |
| CHEMBL4168767 | — | — | 1 | 6.96 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168763 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4175964 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4172110 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4159366 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4167286 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4164238 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4167685 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4160833 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4162254 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4175555 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4170168 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4169802 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4168707 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4165344 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4160840 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4168767 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |