Assay Detail
Functional
CHEMBL4150620
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Antiproliferative activity against human K562 cells after 48 hrs in presence of JAK2 inhibitor CYT-387 by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.66 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078477 | — | — | 1 | 5.79 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.59 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078477 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 2540.0 | nM | 5.59 |