Assay Detail
Binding
CHEMBL4150644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Gq (unknown origin) coupled with muscarinic M1 receptor expressed in CHO cells assessed as reduction in carbachol-induced IP1 accumulation pretreated for 1 hr followed by carbachol addition measured after 35 mins by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173778 | — | — | 1 | 7.79 |
| CHEMBL4170796 | — | — | 1 | 7.79 |
| CHEMBL4171381 | — | — | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173778 | — | IC50 | = | 16.22 | nM | 7.79 |
| CHEMBL4170796 | — | IC50 | = | 16.22 | nM | 7.79 |
| CHEMBL4171381 | — | IC50 | = | 16.22 | nM | 7.79 |