Assay Detail
Binding
CHEMBL4150658
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Inhibition of Influenza A virus (A/California/04/2009(H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/04/2009(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.72 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161935 | — | — | 1 | 9.26 |
| CHEMBL4175983 | — | — | 1 | 8.64 |
| CHEMBL4172581 | — | — | 1 | 8.39 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.37 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.35 |
| CHEMBL4168794 | — | — | 1 | 7.76 |
| CHEMBL4165368 | — | — | 1 | 7.73 |
| CHEMBL3342485 | — | — | 1 | 7.67 |
| CHEMBL4163386 | — | — | 1 | 7.53 |
| CHEMBL4160858 | — | — | 1 | 7.32 |
| CHEMBL4173256 | — | — | 1 | 7.23 |
| CHEMBL4174094 | — | — | 1 | 7.18 |
| CHEMBL4166014 | — | — | 1 | 6.53 |
| CHEMBL4162570 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161935 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4175983 | — | IC50 | = | 2.31 | nM | 8.64 |
| CHEMBL4172581 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4.32 | nM | 8.37 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 4.45 | nM | 8.35 |
| CHEMBL4168794 | — | IC50 | = | 17.31 | nM | 7.76 |
| CHEMBL4165368 | — | IC50 | = | 18.61 | nM | 7.73 |
| CHEMBL3342485 | — | IC50 | = | 21.27 | nM | 7.67 |
| CHEMBL4163386 | — | IC50 | = | 29.82 | nM | 7.53 |
| CHEMBL4160858 | — | IC50 | = | 48.38 | nM | 7.32 |
| CHEMBL4173256 | — | IC50 | = | 59.34 | nM | 7.23 |
| CHEMBL4174094 | — | IC50 | = | 66.72 | nM | 7.18 |
| CHEMBL4166014 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL4162570 | — | IC50 | = | 697.77 | nM | 6.16 |