Assay Detail
Binding
CHEMBL4150659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Babol/36/2005(H3N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.60 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161935 | — | — | 1 | 8.98 |
| CHEMBL4175983 | — | — | 1 | 8.74 |
| CHEMBL4172581 | — | — | 1 | 8.39 |
| CHEMBL4163386 | — | — | 1 | 8.25 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.17 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.15 |
| CHEMBL4168794 | — | — | 1 | 7.96 |
| CHEMBL4165368 | — | — | 1 | 7.77 |
| CHEMBL4174094 | — | — | 1 | 7.51 |
| CHEMBL4160858 | — | — | 1 | 7.20 |
| CHEMBL4173256 | — | — | 1 | 6.49 |
| CHEMBL3342485 | — | — | 1 | 6.45 |
| CHEMBL4162570 | — | — | 1 | 6.32 |
| CHEMBL4166014 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161935 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL4175983 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL4172581 | — | IC50 | = | 4.11 | nM | 8.39 |
| CHEMBL4163386 | — | IC50 | = | 5.65 | nM | 8.25 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 6.82 | nM | 8.17 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 7.14 | nM | 8.15 |
| CHEMBL4168794 | — | IC50 | = | 10.91 | nM | 7.96 |
| CHEMBL4165368 | — | IC50 | = | 17.15 | nM | 7.77 |
| CHEMBL4174094 | — | IC50 | = | 31.12 | nM | 7.51 |
| CHEMBL4160858 | — | IC50 | = | 62.59 | nM | 7.20 |
| CHEMBL4173256 | — | IC50 | = | 327.23 | nM | 6.49 |
| CHEMBL3342485 | — | IC50 | = | 353.5 | nM | 6.45 |
| CHEMBL4162570 | — | IC50 | = | 473.73 | nM | 6.32 |
| CHEMBL4166014 | — | IC50 | = | 869.3 | nM | 6.06 |