Assay Detail
Binding
CHEMBL4150663
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Inhibition of Influenza A virus (A/goose/Jiangsu/1306/2014(H5N8)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.36 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175983 | — | — | 1 | 8.39 |
| CHEMBL4161935 | — | — | 1 | 8.27 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.13 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.11 |
| CHEMBL4172581 | — | — | 1 | 8.02 |
| CHEMBL3342485 | — | — | 1 | 7.75 |
| CHEMBL4163386 | — | — | 1 | 7.54 |
| CHEMBL4173256 | — | — | 1 | 7.36 |
| CHEMBL4165368 | — | — | 1 | 7.24 |
| CHEMBL4168794 | — | — | 1 | 6.66 |
| CHEMBL4160858 | — | — | 1 | 6.54 |
| CHEMBL4166014 | — | — | 1 | 6.44 |
| CHEMBL4174094 | — | — | 1 | 6.43 |
| CHEMBL4162570 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175983 | — | IC50 | = | 4.06 | nM | 8.39 |
| CHEMBL4161935 | — | IC50 | = | 5.34 | nM | 8.27 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 7.39 | nM | 8.13 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 7.77 | nM | 8.11 |
| CHEMBL4172581 | — | IC50 | = | 9.53 | nM | 8.02 |
| CHEMBL3342485 | — | IC50 | = | 17.87 | nM | 7.75 |
| CHEMBL4163386 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4173256 | — | IC50 | = | 43.89 | nM | 7.36 |
| CHEMBL4165368 | — | IC50 | = | 57.46 | nM | 7.24 |
| CHEMBL4168794 | — | IC50 | = | 216.53 | nM | 6.66 |
| CHEMBL4160858 | — | IC50 | = | 288.37 | nM | 6.54 |
| CHEMBL4166014 | — | IC50 | = | 360.7 | nM | 6.44 |
| CHEMBL4174094 | — | IC50 | = | 368.7 | nM | 6.43 |
| CHEMBL4162570 | — | IC50 | = | 817.37 | nM | 6.09 |