Assay Detail
Binding
CHEMBL4150665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Anhui/1/2013(H7N9)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.12 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161935 | — | — | 1 | 8.75 |
| CHEMBL4175983 | — | — | 1 | 8.19 |
| CHEMBL4172581 | — | — | 1 | 8.07 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.07 |
| CHEMBL4163386 | — | — | 1 | 7.94 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.75 |
| CHEMBL4168794 | — | — | 1 | 7.50 |
| CHEMBL4165368 | — | — | 1 | 7.39 |
| CHEMBL4174094 | — | — | 1 | 7.03 |
| CHEMBL4160858 | — | — | 1 | 6.81 |
| CHEMBL3342485 | — | — | 1 | 5.83 |
| CHEMBL4173256 | — | — | 1 | 5.74 |
| CHEMBL4162570 | — | — | 1 | 5.59 |
| CHEMBL4166014 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161935 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL4175983 | — | IC50 | = | 6.51 | nM | 8.19 |
| CHEMBL4172581 | — | IC50 | = | 8.41 | nM | 8.07 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 8.42 | nM | 8.07 |
| CHEMBL4163386 | — | IC50 | = | 11.37 | nM | 7.94 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 17.61 | nM | 7.75 |
| CHEMBL4168794 | — | IC50 | = | 31.47 | nM | 7.50 |
| CHEMBL4165368 | — | IC50 | = | 40.46 | nM | 7.39 |
| CHEMBL4174094 | — | IC50 | = | 94.2 | nM | 7.03 |
| CHEMBL4160858 | — | IC50 | = | 155.9 | nM | 6.81 |
| CHEMBL3342485 | — | IC50 | = | 1463.33 | nM | 5.83 |
| CHEMBL4173256 | — | IC50 | = | 1820.67 | nM | 5.74 |
| CHEMBL4162570 | — | IC50 | = | 2586.0 | nM | 5.59 |
| CHEMBL4166014 | — | IC50 | = | 9123.33 | nM | 5.04 |