Assay Detail
Binding
CHEMBL4150667
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Inhibition of Influenza A virus (A/Babol/36/2005(H3N2)) neuraminidase E119V mutant activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.47 |
| CHEMBL4175983 | — | — | 1 | 6.54 |
| CHEMBL4161935 | — | — | 1 | 6.22 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 33.55 | nM | 7.47 |
| CHEMBL4175983 | — | IC50 | = | 288.5 | nM | 6.54 |
| CHEMBL4161935 | — | IC50 | = | 603.83 | nM | 6.22 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 817.43 | nM | 6.09 |