Assay Detail
Functional
CHEMBL4150682
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Antiviral activity against Influenza A virus A/Chicken/Hebei/LZF/2014(H5N2) infected in chicken embryo fibroblasts assessed as reduction in cytopathic effect after 48 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.51 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161935 | — | — | 1 | 7.92 |
| CHEMBL4175983 | — | — | 1 | 7.20 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.16 |
| CHEMBL4172581 | — | — | 1 | 6.77 |
| CHEMBL4174094 | — | — | 1 | 6.77 |
| CHEMBL4168794 | — | — | 1 | 6.52 |
| CHEMBL4173256 | — | — | 1 | 6.44 |
| CHEMBL4163386 | — | — | 1 | 6.36 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.29 |
| CHEMBL4162570 | — | — | 1 | 6.24 |
| CHEMBL4165368 | — | — | 1 | 6.07 |
| CHEMBL4160858 | — | — | 1 | 5.90 |
| CHEMBL4166014 | — | — | 1 | 5.81 |
| CHEMBL3342485 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161935 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4175983 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4172581 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4174094 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4168794 | — | EC50 | = | 299.0 | nM | 6.52 |
| CHEMBL4173256 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4163386 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4162570 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4165368 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4160858 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4166014 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3342485 | — | EC50 | = | 2190.0 | nM | 5.66 |