Assay Detail
Functional
CHEMBL4150690
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Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as reduction in plaque formation after 2 days by toluidine blue staining-based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.54 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.40 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.30 |
| CHEMBL4161935 | — | — | 1 | 7.16 |
| CHEMBL4175983 | — | — | 1 | 6.66 |
| CHEMBL4173256 | — | — | 1 | 6.16 |
| CHEMBL4163386 | — | — | 1 | 5.71 |
| CHEMBL4160858 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4161935 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4175983 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4173256 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4163386 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4160858 | — | EC50 | = | 4400.0 | nM | 5.36 |