Assay Detail
Binding
CHEMBL4150706
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Inhibition of Influenza B virus neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.11 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.22 |
| CHEMBL4175983 | — | — | 1 | 7.07 |
| CHEMBL4161935 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 60.59 | nM | 7.22 |
| CHEMBL4175983 | — | IC50 | = | 86.04 | nM | 7.07 |
| CHEMBL4161935 | — | IC50 | = | 89.28 | nM | 7.05 |