Assay Detail
Binding
CHEMBL4150708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (H3N2) neuraminidase activity
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus H3N2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Neuraminidase (CHEMBL6015) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Memphis/1/1971(H3N2)) |
Publication
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.05 | 8.40 |
| IC50 | 1 | 7.51 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168935 | — | — | 1 | 8.40 |
| CHEMBL4161008 | — | — | 1 | 7.70 |
| CHEMBL4175711 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168935 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4161008 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4175711 | — | IC50 | = | 31.0 | nM | 7.51 |