Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4150765

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana.
Senadeera SPD, Lucantoni L, Duffy S, Avery VM, Carroll AR.
J Nat Prod (2018) 81 : 1588 -1597
PubMed 29969262 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.59 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 9.40
CHEMBL361497 ARTESUNATE 4.0 1 9.00
CHEMBL36 PYRIMETHAMINE 4.0 1 8.10
CHEMBL76 CHLOROQUINE 4.0 1 8.05
CHEMBL35228 PYRONARIDINE 3.0 1 7.92
CHEMBL469912 PUROMYCIN 2.0 1 7.22
CHEMBL4169291 1 5.50
CHEMBL4164782 1 5.50
CHEMBL4172678 1 5.14
CHEMBL4173089 1 5.14
CHEMBL4163793 1 5.01
CHEMBL4171560 1 4.87
CHEMBL3354990 1 4.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 0.4 nM 9.40
CHEMBL361497 ARTESUNATE IC50 = 1.0 nM 9.00
CHEMBL36 PYRIMETHAMINE IC50 = 8.0 nM 8.10
CHEMBL76 CHLOROQUINE IC50 = 9.0 nM 8.05
CHEMBL35228 PYRONARIDINE IC50 = 12.0 nM 7.92
CHEMBL469912 PUROMYCIN IC50 = 60.0 nM 7.22
CHEMBL4169291 IC50 = 3200.0 nM 5.50
CHEMBL4164782 IC50 = 3200.0 nM 5.50
CHEMBL4172678 IC50 = 7200.0 nM 5.14
CHEMBL4173089 IC50 = 7200.0 nM 5.14
CHEMBL4163793 IC50 = 9800.0 nM 5.01
CHEMBL4171560 IC50 = 13600.0 nM 4.87
CHEMBL3354990 IC50 = 16600.0 nM 4.78