Assay Detail
Functional
CHEMBL4150868
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation preincubated for 5 mins followed by cytochalasin B/fMLP addition for 3 mins by superoxide dismutase inhibitable reduction of ferricytochrome c based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bioactive Phenolic Components from the Twigs of Atalantia buxifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.72 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453805 | PENTOSALEN | -1.0 | 1 | 6.70 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.68 |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | 5.58 |
| CHEMBL71358 | SESALIN | — | 1 | 5.33 |
| CHEMBL4159088 | — | — | 1 | 5.32 |
| CHEMBL452222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453805 | PENTOSALEN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL98350 | LY-294002 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL71358 | SESALIN | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4159088 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL452222 | — | IC50 | > | 10000.0 | nM | - |