Assay Detail
Functional
CHEMBL4150869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release preincubated for 5 mins followed by fMLP/CB stimulation and measured for 10 mins using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bioactive Phenolic Components from the Twigs of Atalantia buxifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.36 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452222 | — | — | 1 | 5.43 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.29 |
| CHEMBL71358 | SESALIN | — | 1 | - |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | - |
| CHEMBL453805 | PENTOSALEN | -1.0 | 1 | - |
| CHEMBL4159088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452222 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL98350 | LY-294002 | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL71358 | SESALIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL453805 | PENTOSALEN | IC50 | > | 10000.0 | nM | - |
| CHEMBL4159088 | — | IC50 | > | 10000.0 | nM | - |