Assay Detail
Binding
CHEMBL4150899
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Inhibition of human p300 expressed in Escherichia coli incubated for 15 mins followed by [3H]acetyl-CoA/histone addition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Swinhoeisterols from the South China Sea Sponge Theonella swinhoei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.61 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445599 | — | — | 1 | 6.30 |
| CHEMBL4166991 | — | — | 1 | 5.48 |
| CHEMBL4173838 | — | — | 1 | 5.06 |
| CHEMBL4165919 | — | — | 1 | - |
| CHEMBL4170395 | — | — | 1 | - |
| CHEMBL4162478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445599 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4166991 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4173838 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4165919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162478 | — | IC50 | > | 10000.0 | nM | - |