Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4150994

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Intermediate

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
Zhao Y, Zhou B, Bai L, Liu L, Yang CY, Meagher JL, Stuckey JA, McEachern D, Przybranowski S, Wang M, Ran X, Aguilar A, Hu Y, Kampf JW, Li X, Zhao T, Li S, Wen B, Sun D, Wang S.
J Med Chem (2018) 61 : 6110 -6120
PubMed 30015487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.31 7.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4171109 1 7.86
CHEMBL4161145 1 7.76
CHEMBL4162784 1 7.63
CHEMBL4167996 1 7.60
CHEMBL4176849 1 7.58
CHEMBL4163185 1 7.58
CHEMBL4174543 1 7.58
CHEMBL4166630 1 7.53
CHEMBL4172277 1 7.26
CHEMBL4169068 1 7.23
CHEMBL4159422 1 7.20
CHEMBL4172447 1 7.17
CHEMBL4175855 1 7.09
CHEMBL4173488 1 7.07
CHEMBL4166235 1 6.81
CHEMBL4170044 1 6.79
CHEMBL4164563 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4171109 IC50 = 13.9 nM 7.86
CHEMBL4161145 IC50 = 17.5 nM 7.76
CHEMBL4162784 IC50 = 23.5 nM 7.63
CHEMBL4167996 IC50 = 25.0 nM 7.60
CHEMBL4176849 IC50 = 26.0 nM 7.58
CHEMBL4163185 IC50 = 26.0 nM 7.58
CHEMBL4174543 IC50 = 26.3 nM 7.58
CHEMBL4166630 IC50 = 29.6 nM 7.53
CHEMBL4172277 IC50 = 55.1 nM 7.26
CHEMBL4169068 IC50 = 58.3 nM 7.23
CHEMBL4159422 IC50 = 63.2 nM 7.20
CHEMBL4172447 IC50 = 67.0 nM 7.17
CHEMBL4175855 IC50 = 81.1 nM 7.09
CHEMBL4173488 IC50 = 85.0 nM 7.07
CHEMBL4166235 IC50 = 156.0 nM 6.81
CHEMBL4170044 IC50 = 164.0 nM 6.79
CHEMBL4164563 IC50 = 319.0 nM 6.50