Assay Detail
Functional
CHEMBL4151157
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Antiproliferative activity against human KMS-12-BM cells after 7 days by cell-titer glo based luminescence assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KMS-12-BM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.22 | 8.22 |
| Imax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168754 | — | — | 2 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168754 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4168754 | — | Imax | = | 99.0 | % | - |