Assay Detail
Functional
CHEMBL4151177
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTT assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
H2O2/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.11 | 6.64 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069207 | — | — | 1 | 6.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.30 |
| CHEMBL4175999 | — | — | 2 | 6.16 |
| CHEMBL226923 | — | — | 1 | 5.95 |
| CHEMBL4165385 | — | — | 2 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069207 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4175999 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL226923 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4165385 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4165385 | — | Activity | - | — | - | |
| CHEMBL4175999 | — | Activity | - | — | - |